NT219
MCE：NT219
Brand：MedChemExpress (MCE)
Cat. No：HY-145935
CAS：1198078-60-2
Purity：98.57%
Storage：-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：NT219 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases[1].
In Vitro：
NT219 (5 μM, 8 or 12 days) suppresses cancer stem cell viability as monotherapy and synergizes with sotorasib to induce disintegration of established mKRAS (G12C) NSCLC spheroids[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo：
NT219 (20 or 60 mg/kg, i.v., twice a week for 24 days) inhibited tumor cell growth and enhanced the anti-cancer effects of Cetuximab (HY-P9905) and Pembrolizumab (HY-P9902) in the SCC-9 cell xenograft model of recurrent and metastatic head and neck squamous cell carcinoma (NOD scid gamma mice)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Hot product：Epalrestat | o-Phenanthroline | Liquiritigenin | Santacruzamate A | Catechin | Stearic acid | Phosphatidylcholines,soya | Livmoniplimab | Fluridone | Clemastine (fumarate)
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
References：
[1]. Alberto Bessudo, et al. A phase 1/2 study with open-label, dose escalation phase followed by single-arm expansion at the maximum tolerated dose to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of NT219 injection alone and in combination with cetuximab in adults with advanced solid tumors and head and neck cancer.
[2]. Reuveni H, et al. NT219, a dual inhibitor of IRS1/2 and STAT3, suppresses cancer stem cell-mediated resistance to KRASG12C and KRASG12D inhibitors in solid tumors[J]. cell, 2024, 3(2): 1.
[3]. Reuveni H, et al. NT219, a novel dual inhibitor of STAT3 and IRS1/2, demonstrates anti-tumor activity with and without cetuximab in pembrolizumab-resistant head and neck cancer PDX models[C]//Cancer Research. 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA: AMER ASSOC CANCER RESEARCH, 2020, 80(16).
Brand Introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing global scientific research customers with the most comprehensive range of high-quality small molecule active compounds;
• More than 50,000 highly selective inhibitors and agonists involved in various popular signaling pathways and disease areas;
• Product categories cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other specialty products, widely used in new drug research and development, life science and other scientific research projects;
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• Professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been experimentally verified by customers from various countries;
A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Professional team to track the latest pharmaceutical and life science research progress, to provide you with the world's latest active compounds;
• Established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions.
