SNAP25 Pre-design Chimera RNAi
产品名称： SNAP25 Pre-design Chimera RNAi
英文名称： SNAP25 Pre-design Chimera RNAi
产品编号： H00006616-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Homo sapiens synaptosomal-associated protein, 25kDa (SNAP25), transcript variant 1, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_003081
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 6616
- Gene Name:
- SNAP25
- Gene Alias:
- FLJ23079,RIC-4,RIC4,SEC9,SNAP,SNAP-25,bA416N4.2,dJ1068F16.2
- Gene Description:
- synaptosomal-associated protein, 25kDa
- Omim ID:
- 600322
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000030267,OTTHUMP00000030268,resistance to inhibitors of cholinesterase 4 homolog,synaptosomal-associated protein 25
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Attention
- Attention Deficit Disorder with Hyperactivity
- Autistic Disorder
- Bipolar Disorder
- Cardiovascular Diseases
- Cognition
- Cognition Disorders
- Depressive Disorder, Major
- Diabetes Complications
- Epilepsy
- Epilepsy
- Genetic Predisposition to Disease
- Memory
- Mental Disorders
- Mental Retardation
- Metabolic Syndrome X
- Narcolepsy