FITC标记的甲基样蛋白16抗体
产品名称： FITC标记的甲基样蛋白16抗体
英文名称： Anti-METT10D/FITC
产品编号： HZ-18811R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-METT10D/FITC Conjugated antibody
FITC标记的甲基样蛋白16抗体
| 英文名称 | Anti-METT10D/FITC |
| 中文名称 | FITC标记的甲基样蛋白16抗体 |
| 别 名 | 2610100D03Rik; 2810013M15Rik; A830095F14Rik; AI846133; Methyltransferase 10 domain containing; Methyltransferase like 16; METT10D; MGC3329; OTTMUSP00000006473; Putative methyltransferase METT10D; RP23-174M12.2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig, Cat, Chimpanzee, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 62kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human METT10D |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: METT10D is a 562 amino acid protein that belongs to the METTL16/rlmF family and methyltransferase superfamily. A putative methyltransferase, METT10D exists as two alternatively spliced isoforms and undergoes phosphorylation in response to DNA damage, most likely by Atm or ATR. The gene encoding METT10D maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, and is linked to predisposition of cancers of the ovary, colon, prostate gland and fallopian tubes. Function: Probable methyltransferase. Similarity: Belongs to the methyltransferase superfamily. METTL16/RlmF family. Database links: Entrez Gene: 468142 Chimpanzee Entrez Gene: 100765063 Chinese Hamster Entrez Gene: 480655 Dog Entrez Gene: 100734997 Guinea pig Entrez Gene: 79066 Human Entrez Gene: 67493 Mouse Entrez Gene: 360568 Rat SwissProt: Q86W50 Human SwissProt: Q9CQG2 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MTET10D是属于MtTL16/RLMF家族和甲基转移酶超家族的562个氨基酸。甲基转移酶，METT10D，作为两种可选择的剪接异构体存在，并经历磷酸化以响应DNA损伤，最可能由Atm或ATR。编码METT10D的基因定位于人类17号染色体，该染色体占人类基因组的2.5%以上，编码1200多个基因。两个关键的肿瘤抑制基因与17号染色体相关，即p53和BRCA1。p53表达的异常或丢失与恶性细胞生长和Li Fraumeni综合征有关。与p53一样，BRCA1直接参与DNA修复，并且与卵巢、结肠、前列腺和输卵管癌的易感性相关。