产品概述：Recombinant protein of human cyclin D1(CCND1), full length, with C-terminal flag tag, expressed in sf9 cells

蛋白长度：A DNA sequence from GoldORF clone, [GH34889V], encoding human full-length CCND1

表达系统：Sf9

种属：Human

标签类型：C-DDK

分子量：34 kDa

通用名：CCND1

总结：The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]

形式：Liquid

浓度：>50 ug/mL as determined by microplate BCA method

纯度：> 80% as determined by SDS-PAGE and Coomassie blue staining

储存溶液：50mM Tris-HCl pH8.0, 150mM NaCl, 10%glycerol

别名：BCL1; D11S287E; PRAD1; U21B31