产品概述：Purified recombinant protein of Human cyclin E1 (CCNE1), transcript variant 1, Ile96-Ala378, with N-terminal His tag, expressed in E. coli, 50ug

蛋白长度：A DNA sequence encoding the region(Ile96-Ala378) of CCNE1

表达系统：E. coli

种属：Human

标签类型：N-His

分子量：32.9 kDa

通用名：CCNE1

总结：The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

形式：Liquid

浓度：>50 ug/mL as determined by microplate BCA method

纯度：> 80% as determined by SDS-PAGE and Coomassie blue staining

储存溶液：50mM Tris, 8M Urea, pH8.0.

别名：CCNE; pCCNE1